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Similarly, Otulak-Kozie et al
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The Journal of Nutrition, 134 (3), 489-492
Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage
A streptozotocin-induced diabetic rat has low taurine in the plasma, cerebrospinal fluid, and brain, which is accompanied by depression-like behavior that was rescued by taurine supplementation (110)
